The Denver MSA has a gross metropolitan product of $157.6 billion in 2010, making it the 18th largest metro economy in the United States.[82] Denver's economy is based partially on its geographic position and its connection to some of the country's major transportation systems. Because Denver is the largest city within 500 miles (800 km), it has become a natural location for storage and distribution of goods and services to the Mountain States, Southwest states, as well as all western states. Another benefit for distribution is that Denver is nearly equidistant from large cities of the Midwest, such as Chicago and St. Louis and some large cities of the West Coast, such as Los Angeles and San Francisco.

Denver is in the center of the Front Range Urban Corridor, between the Rocky Mountains to the west and the High Plains to the east. Denver's topography consists of plains in the city center with hilly areas to the north, west and south. According to the United States Census Bureau the city has a total area of 155 square miles (401 km2), of which 153 square miles (396 km2) is land and 1.6 square miles (4.1 km2) (1.1%) is water.[50] The City and County of Denver is surrounded by only three other counties: Adams County to the north and east, Arapahoe County to the south and east, and Jefferson County to the west.

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