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The Denver MSA has a gross metropolitan product of $157.6 billion in 2010, making it the 18th largest metro economy in the United States.[82] Denver's economy is based partially on its geographic position and its connection to some of the country's major transportation systems. Because Denver is the largest city within 500 miles (800 km), it has become a natural location for storage and distribution of goods and services to the Mountain States, Southwest states, as well as all western states. Another benefit for distribution is that Denver is nearly equidistant from large cities of the Midwest, such as Chicago and St. Louis and some large cities of the West Coast, such as Los Angeles and San Francisco.

Denver also has a nearly complete beltway known as "the 470's". These are SH 470 (also known as C-470), a freeway in the southwest Metro area, and two toll highways, E-470 (from southeast to northeast) and Northwest Parkway (from terminus of E-470 to US 36). SH 470 was intended to be I-470 and built with federal highway funds, but the funding was redirected to complete conversion of downtown Denver's 16th Street to a pedestrian mall. As a result, construction was delayed until 1980 after state and local legislation was passed.[148] I-470 was also once called "The Silver Stake Highway", from Gov. Lamm's declared intention to drive a silver stake through it and kill it.

As of the 2010 census, the population of the City and County of Denver was 600,158, making it the 24th most populous U.S. city.[72] The Denver-Aurora-Lakewood, CO Metropolitan Statistical Area had an estimated 2013 population of 2,697,476 and ranked as the 21st most populous U.S. metropolitan statistical area,[16] and the larger Denver-Aurora-Boulder Combined Statistical Area had an estimated 2013 population of 3,277,309 and ranked as the 16th most populous U.S. metropolitan area.[16] Denver is the most populous city within a radius centered in the city and of 550-mile (890 km) magnitude.[16] Denverites is a term used for residents of Denver.

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